MovDisordV3, Main, Exploration, bibRecord, 000837

Population-specific frequencies for LRRK2 susceptibility variants in the Genetic Epidemiology Of Parkinson’s Disease (GEO-PD) consortium

Identifieur interne : 000837 ( Main/Exploration ); précédent : 000836; suivant : 000838

Population-specific frequencies for LRRK2 susceptibility variants in the Genetic Epidemiology Of Parkinson’s Disease (GEO-PD) consortium

Auteurs : Michael G. Heckman [États-Unis] ; Alexandra I. Soto-Ortolaza [États-Unis] ; Jan O. Aasly [Norvège] ; Nadine Abahuni [Allemagne] ; Grazia Annesi ; Justin A. Bacon [États-Unis] ; Soraya Bardien [Afrique du Sud] ; Maria Bozi [Grèce] ; Alexis Brice [France] ; Laura Brighina [Italie] ; Jonathan Carr [Afrique du Sud] ; Marie-Christine Chartier-Harlin [France] ; Efthimios Dardiotis [Grèce] ; Dennis W. Dickson [États-Unis] ; Nancy N. Diehl [États-Unis] ; Alexis Elbaz [France] ; Carlo Ferrarese [Italie] ; Brian Fiske [États-Unis] ; J. Mark Gibson [Irlande (pays)] ; Rachel Gibson [Royaume-Uni] ; Georgios M. Hadjigeorgiou [Grèce] ; Nobutaka Hattori [Japon] ; Faycal Hentati [Tunisie] ; John P. A. Ioannidis [Grèce, États-Unis] ; Magdalena Boczarska-Jedynak [Pologne] ; Barbara Jasinska-Myga [Pologne] ; Beom S. Jeon [Corée du Sud] ; Yun Joong Kim [Corée du Sud] ; Christine Klein [Allemagne] ; Rejko Kruger [Allemagne] ; Elli Kyratzi [Grèce] ; Suzanne Lesage [France] ; Chin-Hsien Lin [Taïwan] ; Timothy Lynch [Irlande (pays)] ; Demetrius M. Maraganore [États-Unis] ; George D. Mellick [Australie] ; Eugénie Mutez [France] ; Christer Nilsson [Suède] ; Grzegorz Opala [Pologne] ; Sung Sup Park [Corée du Sud] ; Simona Petrucci [Italie] ; Andreas Puschmann [Suède] ; Aldo Quattrone [Italie] ; Manu Sharma [Allemagne] ; Peter A. Silburn [Australie] ; Young Ho Sohn [Corée du Sud] ; Leonidas Stefanis [Grèce] ; Vera Tadic [Allemagne] ; Jessie Theuns [Belgique] ; Hiroyuki Tomiyama [Japon] ; Ryan J. Uitti [États-Unis] ; Enza Maria Valente [Italie] ; Christine Van Broeckhoven [Belgique] ; Simone Van De Loo [Allemagne] ; Demetrios K. Vassilatis [Grèce] ; Carles Vilari O-Güell [Canada] ; Linda R. White [Norvège] ; Karin Wirdefeldt [Suède] ; Zbigniew K. Wszolek [Belgique] ; Ruey-Meei Wu [Taïwan] ; Matthew J. Farrer [Canada] ; Owen A. Ross [États-Unis]

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2013.

RBID : PMC:4108155

English descriptors

KwdEn :
- Gene Frequency, Genetic Association Studies, Genetic Predisposition to Disease, Genetics, Population, Genotype, Haplotypes, Humans, Molecular Epidemiology, Parkinson Disease (epidemiology), Parkinson Disease (genetics), Polymorphism, Single Nucleotide, Protein-Serine-Threonine Kinases (genetics).
MESH :
- chemical , genetics : Protein-Serine-Threonine Kinases.
- epidemiology : Parkinson Disease.
- genetics : Parkinson Disease.
- Gene Frequency, Genetic Association Studies, Genetic Predisposition to Disease, Genetics, Population, Genotype, Haplotypes, Humans, Molecular Epidemiology, Polymorphism, Single Nucleotide.

Abstract

Variants within the leucine-rich repeat kinase 2 gene are recognized as the most frequent genetic cause of Parkinson’s disease. Leucine-rich repeat kinase 2 variation related to susceptibility to disease displays many features that reflect the nature of complex late-onset sporadic disorders, such as Parkinson’s disease. The Genetic Epidemiology of Parkinson’s disease consortium recently performed the largest genetic association study for variants in the leucine-rich repeat kinase 2 gene across 23 different sites in 15 countries. Herein we detail the allele frequencies for the novel risk factors (p.A419V and p.M1646T) and the protective haplotype (p.N551K-R1398H-K1423K) reported in the original publication. Simple population allele frequencies can not only provide an insight into the clinical relevance of specific variants but also help genetically define patient groups. Establishing individual patient-based genomic susceptibility profiles incorporating both risk and protective factors will determine future diagnostic and treatment strategies.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108155

DOI: 10.1002/mds.25600
PubMed: 23913756
PubMed Central: 4108155

Affiliations:

Afrique du Sud, Allemagne, Australie, Belgique, Canada, Corée du Sud, France, Grèce, Irlande (pays), Italie, Japon, Norvège, Pologne, Royaume-Uni, Suède, Taïwan, Tunisie, États-Unis
Angleterre, Californie, Floride, Illinois, Nord-Pas-de-Calais, Nord-Pas-de-Calais-Picardie, Province d'Anvers, Svealand, Trøndelag, État de New York, Île-de-France
Anvers, Lille, Paris, Stockholm, Séoul, Tokyo, Trondheim, Villejuif
Université d'Anvers

Le document en format XML

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<author><name sortKey="Diehl, Nancy N" sort="Diehl, Nancy N" uniqKey="Diehl N" first="Nancy N." last="Diehl">Nancy N. Diehl</name>
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<author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name>
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<affiliation wicri:level="1"><nlm:aff id="A19">Université de Versailles Saint-Quentin, UMRS 1018, France</nlm:aff>
<country xml:lang="fr">France</country>
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<author><name sortKey="Ferrarese, Carlo" sort="Ferrarese, Carlo" uniqKey="Ferrarese C" first="Carlo" last="Ferrarese">Carlo Ferrarese</name>
<affiliation wicri:level="1"><nlm:aff id="A12">Department of Neuroscience-Section of Neurology, University of Milano-Bicocca, San Gerardo Hospital, Monza, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Neuroscience-Section of Neurology, University of Milano-Bicocca, San Gerardo Hospital, Monza</wicri:regionArea>
<wicri:noRegion>Monza</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fiske, Brian" sort="Fiske, Brian" uniqKey="Fiske B" first="Brian" last="Fiske">Brian Fiske</name>
<affiliation wicri:level="2"><nlm:aff id="A20">The Michael J Fox Foundation for Parkinson’s Research, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Michael J Fox Foundation for Parkinson’s Research, New York, NY</wicri:regionArea>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Gibson, J Mark" sort="Gibson, J Mark" uniqKey="Gibson J" first="J. Mark" last="Gibson">J. Mark Gibson</name>
<affiliation wicri:level="1"><nlm:aff id="A21">Department of Neurology, Royal Victoria Hospital, Belfast, Ireland</nlm:aff>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>Department of Neurology, Royal Victoria Hospital, Belfast</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Gibson, Rachel" sort="Gibson, Rachel" uniqKey="Gibson R" first="Rachel" last="Gibson">Rachel Gibson</name>
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<country>Royaume-Uni</country>
<placeName><region type="country">Angleterre</region>
</placeName>
<wicri:cityArea>Research and Development, GlaxoSmithKline Pharmaceuticals Ltd., Stevenage</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hadjigeorgiou, Georgios M" sort="Hadjigeorgiou, Georgios M" uniqKey="Hadjigeorgiou G" first="Georgios M." last="Hadjigeorgiou">Georgios M. Hadjigeorgiou</name>
<affiliation wicri:level="1"><nlm:aff id="A16">Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa</wicri:regionArea>
<wicri:noRegion>Larissa</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A17">Institute of Biomedical Research & Technology, CERETETH, Larissa, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Institute of Biomedical Research & Technology, CERETETH, Larissa</wicri:regionArea>
<wicri:noRegion>Larissa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hattori, Nobutaka" sort="Hattori, Nobutaka" uniqKey="Hattori N" first="Nobutaka" last="Hattori">Nobutaka Hattori</name>
<affiliation wicri:level="3"><nlm:aff id="A23">Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Neurology, Juntendo University School of Medicine, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hentati, Faycal" sort="Hentati, Faycal" uniqKey="Hentati F" first="Faycal" last="Hentati">Faycal Hentati</name>
<affiliation wicri:level="1"><nlm:aff id="A24">Service de Neurologie, Institut National de Neurologie, 1007 La Rabta, Tunis, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Service de Neurologie, Institut National de Neurologie, 1007 La Rabta, Tunis</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Ioannidis, John P A" sort="Ioannidis, John P A" uniqKey="Ioannidis J" first="John P. A." last="Ioannidis">John P. A. Ioannidis</name>
<affiliation wicri:level="1"><nlm:aff id="A25">Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina</wicri:regionArea>
<wicri:noRegion>Ioannina</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A26">Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Boczarska Jedynak, Magdalena" sort="Boczarska Jedynak, Magdalena" uniqKey="Boczarska Jedynak M" first="Magdalena" last="Boczarska-Jedynak">Magdalena Boczarska-Jedynak</name>
<affiliation wicri:level="1"><nlm:aff id="A27">Department of Neurology, Medical University of Silesia, Katowice, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Neurology, Medical University of Silesia, Katowice</wicri:regionArea>
<wicri:noRegion>Katowice</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jasinska Myga, Barbara" sort="Jasinska Myga, Barbara" uniqKey="Jasinska Myga B" first="Barbara" last="Jasinska-Myga">Barbara Jasinska-Myga</name>
<affiliation wicri:level="1"><nlm:aff id="A27">Department of Neurology, Medical University of Silesia, Katowice, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Neurology, Medical University of Silesia, Katowice</wicri:regionArea>
<wicri:noRegion>Katowice</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jeon, Beom S" sort="Jeon, Beom S" uniqKey="Jeon B" first="Beom S." last="Jeon">Beom S. Jeon</name>
<affiliation wicri:level="1"><nlm:aff id="A28">Department of Neurology, Seoul National University Hospital, Seoul 110-744, South Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Neurology, Seoul National University Hospital, Seoul 110-744</wicri:regionArea>
<placeName><settlement type="city">Séoul</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kim, Yun Joong" sort="Kim, Yun Joong" uniqKey="Kim Y" first="Yun Joong" last="Kim">Yun Joong Kim</name>
<affiliation wicri:level="1"><nlm:aff id="A29">ILSONG Institute of Life Science and Department of Neurology, Hallym University, Anyang, South Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>ILSONG Institute of Life Science and Department of Neurology, Hallym University, Anyang</wicri:regionArea>
<wicri:noRegion>Anyang</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name>
<affiliation wicri:level="1"><nlm:aff id="A30">Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Luebeck, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Luebeck</wicri:regionArea>
<wicri:noRegion>University of Luebeck</wicri:noRegion>
<wicri:noRegion>University of Luebeck</wicri:noRegion>
<wicri:noRegion>University of Luebeck</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kruger, Rejko" sort="Kruger, Rejko" uniqKey="Kruger R" first="Rejko" last="Kruger">Rejko Kruger</name>
<affiliation wicri:level="1"><nlm:aff id="A31">Department for Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases (DZNE), University of Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department for Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases (DZNE), University of Tübingen</wicri:regionArea>
<wicri:noRegion>University of Tübingen</wicri:noRegion>
<wicri:noRegion>University of Tübingen</wicri:noRegion>
<wicri:noRegion>University of Tübingen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kyratzi, Elli" sort="Kyratzi, Elli" uniqKey="Kyratzi E" first="Elli" last="Kyratzi">Elli Kyratzi</name>
<affiliation wicri:level="1"><nlm:aff id="A32">Divisions of Basic Neurosciences and Cell Biology, Biomedical Research Foundation of the Academy of Athens, Athens 11527, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Divisions of Basic Neurosciences and Cell Biology, Biomedical Research Foundation of the Academy of Athens, Athens 11527</wicri:regionArea>
<wicri:noRegion>Athens 11527</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lesage, Suzanne" sort="Lesage, Suzanne" uniqKey="Lesage S" first="Suzanne" last="Lesage">Suzanne Lesage</name>
<affiliation wicri:level="1"><nlm:aff id="A8">Université Pierre et Marie Curie-Paris6, Centre de Recherche de l’Institut du Cerveau et de la Moelle épinière, UMR-S975, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Pierre et Marie Curie-Paris6, Centre de Recherche de l’Institut du Cerveau et de la Moelle épinière, UMR-S975, Paris</wicri:regionArea>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A9">Inserm, U975, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm, U975, Paris</wicri:regionArea>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A10">Cnrs, UMR 7225, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Cnrs, UMR 7225, Paris</wicri:regionArea>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lin, Chin Hsien" sort="Lin, Chin Hsien" uniqKey="Lin C" first="Chin-Hsien" last="Lin">Chin-Hsien Lin</name>
<affiliation wicri:level="1"><nlm:aff id="A33">Department of Neurology, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Neurology, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin</wicri:regionArea>
<wicri:noRegion>Yun-Lin</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lynch, Timothy" sort="Lynch, Timothy" uniqKey="Lynch T" first="Timothy" last="Lynch">Timothy Lynch</name>
<affiliation wicri:level="1"><nlm:aff id="A34">Dublin Neurological Institute at the Mater Misericordiae University Hospital, and Conway Institute of Biomolecular & Biomedical Research, University College Dublin, Ireland</nlm:aff>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>Dublin Neurological Institute at the Mater Misericordiae University Hospital, and Conway Institute of Biomolecular & Biomedical Research, University College Dublin</wicri:regionArea>
<wicri:noRegion>University College Dublin</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name>
<affiliation wicri:level="2"><nlm:aff id="A35">Department of Neurology, NorthShore University HealthSystem, Evanston, IL</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Department of Neurology, NorthShore University HealthSystem, Evanston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D." last="Mellick">George D. Mellick</name>
<affiliation wicri:level="1"><nlm:aff id="A36">Eskitis Institute for Cell and Molecular Therapies, Griffith University, Queensland, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Eskitis Institute for Cell and Molecular Therapies, Griffith University, Queensland</wicri:regionArea>
<wicri:noRegion>Queensland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mutez, Eugenie" sort="Mutez, Eugenie" uniqKey="Mutez E" first="Eugénie" last="Mutez">Eugénie Mutez</name>
<affiliation wicri:level="1"><nlm:aff id="A14">University Lille Nord de France, Centre de recherche Jean-Pierre Aubert, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Lille Nord de France, Centre de recherche Jean-Pierre Aubert, Lille</wicri:regionArea>
<placeName><settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A15">INSERM, U837, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM, U837, Lille</wicri:regionArea>
<placeName><settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A37">Centre Hospitalier Regional Universitaire de Lille, 59037 Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Hospitalier Regional Universitaire de Lille, 59037 Lille</wicri:regionArea>
<placeName><region type="region" nuts="2">Nord-Pas-de-Calais-Picardie</region>
<region type="old region" nuts="2">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nilsson, Christer" sort="Nilsson, Christer" uniqKey="Nilsson C" first="Christer" last="Nilsson">Christer Nilsson</name>
<affiliation wicri:level="1"><nlm:aff id="A38">Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Clinical Memory Research Unit, Department of Clinical Sciences, Lund University</wicri:regionArea>
<wicri:noRegion>Lund University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Opala, Grzegorz" sort="Opala, Grzegorz" uniqKey="Opala G" first="Grzegorz" last="Opala">Grzegorz Opala</name>
<affiliation wicri:level="1"><nlm:aff id="A27">Department of Neurology, Medical University of Silesia, Katowice, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Neurology, Medical University of Silesia, Katowice</wicri:regionArea>
<wicri:noRegion>Katowice</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Park, Sung Sup" sort="Park, Sung Sup" uniqKey="Park S" first="Sung Sup" last="Park">Sung Sup Park</name>
<affiliation wicri:level="1"><nlm:aff id="A39">Department of Laboratory Medicine, Seoul National University Hospital, Seoul 110-744, South Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Laboratory Medicine, Seoul National University Hospital, Seoul 110-744</wicri:regionArea>
<placeName><settlement type="city">Séoul</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Petrucci, Simona" sort="Petrucci, Simona" uniqKey="Petrucci S" first="Simona" last="Petrucci">Simona Petrucci</name>
<affiliation wicri:level="1"><nlm:aff id="A40">IRCCS Casa Sollievo della Sofferenza Hospital, Mendel Laboratory, San Giovanni Rotondo, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>IRCCS Casa Sollievo della Sofferenza Hospital, Mendel Laboratory, San Giovanni Rotondo</wicri:regionArea>
<wicri:noRegion>San Giovanni Rotondo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Puschmann, Andreas" sort="Puschmann, Andreas" uniqKey="Puschmann A" first="Andreas" last="Puschmann">Andreas Puschmann</name>
<affiliation wicri:level="1"><nlm:aff id="A41">Department of Neurology, Skåne University Hospital, Lund, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Neurology, Skåne University Hospital, Lund</wicri:regionArea>
<wicri:noRegion>Lund</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A42">Department of Neurology, Clinical Sciences, Lund University, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Neurology, Clinical Sciences, Lund University</wicri:regionArea>
<wicri:noRegion>Lund University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name>
<affiliation wicri:level="1"><nlm:aff id="A43">Department of Medical Sciences, Institute of Neurology, University Magna Graecia, and Neuroimaging Research Unit, National Research Council, Catanzaro, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Medical Sciences, Institute of Neurology, University Magna Graecia, and Neuroimaging Research Unit, National Research Council, Catanzaro</wicri:regionArea>
<wicri:noRegion>Catanzaro</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sharma, Manu" sort="Sharma, Manu" uniqKey="Sharma M" first="Manu" last="Sharma">Manu Sharma</name>
<affiliation wicri:level="1"><nlm:aff id="A31">Department for Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases (DZNE), University of Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department for Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases (DZNE), University of Tübingen</wicri:regionArea>
<wicri:noRegion>University of Tübingen</wicri:noRegion>
<wicri:noRegion>University of Tübingen</wicri:noRegion>
<wicri:noRegion>University of Tübingen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A." last="Silburn">Peter A. Silburn</name>
<affiliation wicri:level="1"><nlm:aff id="A44">University of Queensland, Centre for Clinical Research, Royal Brisbane Hospital, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>University of Queensland, Centre for Clinical Research, Royal Brisbane Hospital</wicri:regionArea>
<wicri:noRegion>Royal Brisbane Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sohn, Young Ho" sort="Sohn, Young Ho" uniqKey="Sohn Y" first="Young Ho" last="Sohn">Young Ho Sohn</name>
<affiliation wicri:level="3"><nlm:aff id="A45">Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Neurology, Yonsei University College of Medicine, Seoul</wicri:regionArea>
<placeName><settlement type="city">Séoul</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stefanis, Leonidas" sort="Stefanis, Leonidas" uniqKey="Stefanis L" first="Leonidas" last="Stefanis">Leonidas Stefanis</name>
<affiliation wicri:level="1"><nlm:aff id="A32">Divisions of Basic Neurosciences and Cell Biology, Biomedical Research Foundation of the Academy of Athens, Athens 11527, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Divisions of Basic Neurosciences and Cell Biology, Biomedical Research Foundation of the Academy of Athens, Athens 11527</wicri:regionArea>
<wicri:noRegion>Athens 11527</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tadic, Vera" sort="Tadic, Vera" uniqKey="Tadic V" first="Vera" last="Tadic">Vera Tadic</name>
<affiliation wicri:level="1"><nlm:aff id="A30">Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Luebeck, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Luebeck</wicri:regionArea>
<wicri:noRegion>University of Luebeck</wicri:noRegion>
<wicri:noRegion>University of Luebeck</wicri:noRegion>
<wicri:noRegion>University of Luebeck</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Theuns, Jessie" sort="Theuns, Jessie" uniqKey="Theuns J" first="Jessie" last="Theuns">Jessie Theuns</name>
<affiliation wicri:level="1"><nlm:aff id="A46">Neurodegenerative Brain Diseases group, Department of Molecular Genetics, VIB, Antwerp, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Neurodegenerative Brain Diseases group, Department of Molecular Genetics, VIB, Antwerp</wicri:regionArea>
<wicri:noRegion>Antwerp</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A47">Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp</wicri:regionArea>
<orgName type="university">Université d'Anvers</orgName>
<placeName><settlement type="city">Anvers</settlement>
<region type="district" nuts="2">Province d'Anvers</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tomiyama, Hiroyuki" sort="Tomiyama, Hiroyuki" uniqKey="Tomiyama H" first="Hiroyuki" last="Tomiyama">Hiroyuki Tomiyama</name>
<affiliation wicri:level="3"><nlm:aff id="A23">Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Neurology, Juntendo University School of Medicine, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Uitti, Ryan J" sort="Uitti, Ryan J" uniqKey="Uitti R" first="Ryan J." last="Uitti">Ryan J. Uitti</name>
<affiliation wicri:level="2"><nlm:aff id="A48">Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Mayo Clinic, Jacksonville, Florida</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Valente, Enza Maria" sort="Valente, Enza Maria" uniqKey="Valente E" first="Enza Maria" last="Valente">Enza Maria Valente</name>
<affiliation wicri:level="1"><nlm:aff id="A40">IRCCS Casa Sollievo della Sofferenza Hospital, Mendel Laboratory, San Giovanni Rotondo, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>IRCCS Casa Sollievo della Sofferenza Hospital, Mendel Laboratory, San Giovanni Rotondo</wicri:regionArea>
<wicri:noRegion>San Giovanni Rotondo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Broeckhoven, Christine" sort="Van Broeckhoven, Christine" uniqKey="Van Broeckhoven C" first="Christine" last="Van Broeckhoven">Christine Van Broeckhoven</name>
<affiliation wicri:level="1"><nlm:aff id="A46">Neurodegenerative Brain Diseases group, Department of Molecular Genetics, VIB, Antwerp, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Neurodegenerative Brain Diseases group, Department of Molecular Genetics, VIB, Antwerp</wicri:regionArea>
<wicri:noRegion>Antwerp</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A47">Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp</wicri:regionArea>
<orgName type="university">Université d'Anvers</orgName>
<placeName><settlement type="city">Anvers</settlement>
<region type="district" nuts="2">Province d'Anvers</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van De Loo, Simone" sort="Van De Loo, Simone" uniqKey="Van De Loo S" first="Simone" last="Van De Loo">Simone Van De Loo</name>
<affiliation wicri:level="1"><nlm:aff id="A4">Department of Neurology, Goethe University Frankfurt am Main, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Goethe University Frankfurt am Main</wicri:regionArea>
<wicri:noRegion>Goethe University Frankfurt am Main</wicri:noRegion>
<wicri:noRegion>Goethe University Frankfurt am Main</wicri:noRegion>
<wicri:noRegion>Goethe University Frankfurt am Main</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vassilatis, Demetrios K" sort="Vassilatis, Demetrios K" uniqKey="Vassilatis D" first="Demetrios K." last="Vassilatis">Demetrios K. Vassilatis</name>
<affiliation wicri:level="1"><nlm:aff id="A32">Divisions of Basic Neurosciences and Cell Biology, Biomedical Research Foundation of the Academy of Athens, Athens 11527, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Divisions of Basic Neurosciences and Cell Biology, Biomedical Research Foundation of the Academy of Athens, Athens 11527</wicri:regionArea>
<wicri:noRegion>Athens 11527</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vilari O Guell, Carles" sort="Vilari O Guell, Carles" uniqKey="Vilari O Guell C" first="Carles" last="Vilari O-Güell">Carles Vilari O-Güell</name>
<affiliation wicri:level="1"><nlm:aff id="A49">Department of Medical Genetics, University of British Columbia, Vancouver, V5Z 4H4 BC, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Medical Genetics, University of British Columbia, Vancouver, V5Z 4H4 BC</wicri:regionArea>
<wicri:noRegion>V5Z 4H4 BC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="White, Linda R" sort="White, Linda R" uniqKey="White L" first="Linda R." last="White">Linda R. White</name>
<affiliation wicri:level="3"><nlm:aff id="A50">University Hospital and NTNU, Trondheim, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>University Hospital and NTNU, Trondheim</wicri:regionArea>
<placeName><settlement type="city">Trondheim</settlement>
<region type="région" nuts="2">Trøndelag</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wirdefeldt, Karin" sort="Wirdefeldt, Karin" uniqKey="Wirdefeldt K" first="Karin" last="Wirdefeldt">Karin Wirdefeldt</name>
<affiliation wicri:level="3"><nlm:aff id="A51">Department of Clinical Neuroscience and Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Clinical Neuroscience and Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name>
<affiliation wicri:level="4"><nlm:aff id="A47">Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp</wicri:regionArea>
<orgName type="university">Université d'Anvers</orgName>
<placeName><settlement type="city">Anvers</settlement>
<region type="district" nuts="2">Province d'Anvers</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wu, Ruey Meei" sort="Wu, Ruey Meei" uniqKey="Wu R" first="Ruey-Meei" last="Wu">Ruey-Meei Wu</name>
<affiliation wicri:level="1"><nlm:aff id="A52">Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei</wicri:regionArea>
<wicri:noRegion>Taipei</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J." last="Farrer">Matthew J. Farrer</name>
<affiliation wicri:level="1"><nlm:aff id="A49">Department of Medical Genetics, University of British Columbia, Vancouver, V5Z 4H4 BC, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Medical Genetics, University of British Columbia, Vancouver, V5Z 4H4 BC</wicri:regionArea>
<wicri:noRegion>V5Z 4H4 BC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ross, Owen A" sort="Ross, Owen A" uniqKey="Ross O" first="Owen A." last="Ross">Owen A. Ross</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Population-specific frequencies for <italic>LRRK2</italic>
 susceptibility variants in the Genetic Epidemiology Of Parkinson’s Disease (GEO-PD) consortium</title>
<author><name sortKey="Heckman, Michael G" sort="Heckman, Michael G" uniqKey="Heckman M" first="Michael G." last="Heckman">Michael G. Heckman</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Biostatistics Unit, Mayo Clinic, Jacksonville, Florida, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Biostatistics Unit, Mayo Clinic, Jacksonville, Florida</wicri:regionArea>
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</affiliation>
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<author><name sortKey="Soto Ortolaza, Alexandra I" sort="Soto Ortolaza, Alexandra I" uniqKey="Soto Ortolaza A" first="Alexandra I." last="Soto-Ortolaza">Alexandra I. Soto-Ortolaza</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Aasly, Jan O" sort="Aasly, Jan O" uniqKey="Aasly J" first="Jan O." last="Aasly">Jan O. Aasly</name>
<affiliation wicri:level="3"><nlm:aff id="A3">Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of Neuroscience, Norwegian University of Science and Technology, Trondheim</wicri:regionArea>
<placeName><settlement type="city">Trondheim</settlement>
<region type="région" nuts="2">Trøndelag</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Abahuni, Nadine" sort="Abahuni, Nadine" uniqKey="Abahuni N" first="Nadine" last="Abahuni">Nadine Abahuni</name>
<affiliation wicri:level="1"><nlm:aff id="A4">Department of Neurology, Goethe University Frankfurt am Main, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Goethe University Frankfurt am Main</wicri:regionArea>
<wicri:noRegion>Goethe University Frankfurt am Main</wicri:noRegion>
<wicri:noRegion>Goethe University Frankfurt am Main</wicri:noRegion>
<wicri:noRegion>Goethe University Frankfurt am Main</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Annesi, Grazia" sort="Annesi, Grazia" uniqKey="Annesi G" first="Grazia" last="Annesi">Grazia Annesi</name>
<affiliation><nlm:aff id="A5">Institute of Neurological Sciences, National Research Council, Cosenza Italy</nlm:aff>
<wicri:noCountry code="subfield">Cosenza Italy</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Bacon, Justin A" sort="Bacon, Justin A" uniqKey="Bacon J" first="Justin A." last="Bacon">Justin A. Bacon</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bardien, Soraya" sort="Bardien, Soraya" uniqKey="Bardien S" first="Soraya" last="Bardien">Soraya Bardien</name>
<affiliation wicri:level="1"><nlm:aff id="A6">Division of Molecular Biology and Human Genetics, University of Stellenbosch, Cape Town, South Africa</nlm:aff>
<country xml:lang="fr">Afrique du Sud</country>
<wicri:regionArea>Division of Molecular Biology and Human Genetics, University of Stellenbosch, Cape Town</wicri:regionArea>
<wicri:noRegion>Cape Town</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bozi, Maria" sort="Bozi, Maria" uniqKey="Bozi M" first="Maria" last="Bozi">Maria Bozi</name>
<affiliation wicri:level="1"><nlm:aff id="A7">General Hospital of Syros, Syros, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>General Hospital of Syros, Syros</wicri:regionArea>
<wicri:noRegion>Syros</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name>
<affiliation wicri:level="1"><nlm:aff id="A8">Université Pierre et Marie Curie-Paris6, Centre de Recherche de l’Institut du Cerveau et de la Moelle épinière, UMR-S975, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Pierre et Marie Curie-Paris6, Centre de Recherche de l’Institut du Cerveau et de la Moelle épinière, UMR-S975, Paris</wicri:regionArea>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A9">Inserm, U975, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm, U975, Paris</wicri:regionArea>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A10">Cnrs, UMR 7225, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Cnrs, UMR 7225, Paris</wicri:regionArea>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A11">AP-HP, Hôpital de la Salpêtrière, Department of Genetics and Cytogenetics, F-75013, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>AP-HP, Hôpital de la Salpêtrière, Department of Genetics and Cytogenetics, F-75013, Paris</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Brighina, Laura" sort="Brighina, Laura" uniqKey="Brighina L" first="Laura" last="Brighina">Laura Brighina</name>
<affiliation wicri:level="1"><nlm:aff id="A12">Department of Neuroscience-Section of Neurology, University of Milano-Bicocca, San Gerardo Hospital, Monza, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Neuroscience-Section of Neurology, University of Milano-Bicocca, San Gerardo Hospital, Monza</wicri:regionArea>
<wicri:noRegion>Monza</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Carr, Jonathan" sort="Carr, Jonathan" uniqKey="Carr J" first="Jonathan" last="Carr">Jonathan Carr</name>
<affiliation wicri:level="1"><nlm:aff id="A13">Division of Neurology, University of Stellenbosch, Cape Town, South Africa</nlm:aff>
<country xml:lang="fr">Afrique du Sud</country>
<wicri:regionArea>Division of Neurology, University of Stellenbosch, Cape Town</wicri:regionArea>
<wicri:noRegion>Cape Town</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chartier Harlin, Marie Christine" sort="Chartier Harlin, Marie Christine" uniqKey="Chartier Harlin M" first="Marie-Christine" last="Chartier-Harlin">Marie-Christine Chartier-Harlin</name>
<affiliation wicri:level="1"><nlm:aff id="A14">University Lille Nord de France, Centre de recherche Jean-Pierre Aubert, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Lille Nord de France, Centre de recherche Jean-Pierre Aubert, Lille</wicri:regionArea>
<placeName><settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A15">INSERM, U837, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM, U837, Lille</wicri:regionArea>
<placeName><settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dardiotis, Efthimios" sort="Dardiotis, Efthimios" uniqKey="Dardiotis E" first="Efthimios" last="Dardiotis">Efthimios Dardiotis</name>
<affiliation wicri:level="1"><nlm:aff id="A16">Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa</wicri:regionArea>
<wicri:noRegion>Larissa</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A17">Institute of Biomedical Research & Technology, CERETETH, Larissa, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Institute of Biomedical Research & Technology, CERETETH, Larissa</wicri:regionArea>
<wicri:noRegion>Larissa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dickson, Dennis W" sort="Dickson, Dennis W" uniqKey="Dickson D" first="Dennis W." last="Dickson">Dennis W. Dickson</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Diehl, Nancy N" sort="Diehl, Nancy N" uniqKey="Diehl N" first="Nancy N." last="Diehl">Nancy N. Diehl</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Biostatistics Unit, Mayo Clinic, Jacksonville, Florida, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Biostatistics Unit, Mayo Clinic, Jacksonville, Florida</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name>
<affiliation wicri:level="3"><nlm:aff id="A18">INSERM, U1018, CESP Centre for Research in Epidemiology and Population Health, F- 94807, Villejuif, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM, U1018, CESP Centre for Research in Epidemiology and Population Health, F- 94807, Villejuif</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Villejuif</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A19">Université de Versailles Saint-Quentin, UMRS 1018, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université de Versailles Saint-Quentin, UMRS 1018</wicri:regionArea>
<wicri:noRegion>UMRS 1018</wicri:noRegion>
<wicri:noRegion>UMRS 1018</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ferrarese, Carlo" sort="Ferrarese, Carlo" uniqKey="Ferrarese C" first="Carlo" last="Ferrarese">Carlo Ferrarese</name>
<affiliation wicri:level="1"><nlm:aff id="A12">Department of Neuroscience-Section of Neurology, University of Milano-Bicocca, San Gerardo Hospital, Monza, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Neuroscience-Section of Neurology, University of Milano-Bicocca, San Gerardo Hospital, Monza</wicri:regionArea>
<wicri:noRegion>Monza</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fiske, Brian" sort="Fiske, Brian" uniqKey="Fiske B" first="Brian" last="Fiske">Brian Fiske</name>
<affiliation wicri:level="2"><nlm:aff id="A20">The Michael J Fox Foundation for Parkinson’s Research, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Michael J Fox Foundation for Parkinson’s Research, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gibson, J Mark" sort="Gibson, J Mark" uniqKey="Gibson J" first="J. Mark" last="Gibson">J. Mark Gibson</name>
<affiliation wicri:level="1"><nlm:aff id="A21">Department of Neurology, Royal Victoria Hospital, Belfast, Ireland</nlm:aff>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>Department of Neurology, Royal Victoria Hospital, Belfast</wicri:regionArea>
<wicri:noRegion>Belfast</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gibson, Rachel" sort="Gibson, Rachel" uniqKey="Gibson R" first="Rachel" last="Gibson">Rachel Gibson</name>
<affiliation wicri:level="2"><nlm:aff id="A22">Research and Development, GlaxoSmithKline Pharmaceuticals Ltd., Stevenage, England</nlm:aff>
<country>Royaume-Uni</country>
<placeName><region type="country">Angleterre</region>
</placeName>
<wicri:cityArea>Research and Development, GlaxoSmithKline Pharmaceuticals Ltd., Stevenage</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hadjigeorgiou, Georgios M" sort="Hadjigeorgiou, Georgios M" uniqKey="Hadjigeorgiou G" first="Georgios M." last="Hadjigeorgiou">Georgios M. Hadjigeorgiou</name>
<affiliation wicri:level="1"><nlm:aff id="A16">Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa</wicri:regionArea>
<wicri:noRegion>Larissa</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A17">Institute of Biomedical Research & Technology, CERETETH, Larissa, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Institute of Biomedical Research & Technology, CERETETH, Larissa</wicri:regionArea>
<wicri:noRegion>Larissa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hattori, Nobutaka" sort="Hattori, Nobutaka" uniqKey="Hattori N" first="Nobutaka" last="Hattori">Nobutaka Hattori</name>
<affiliation wicri:level="3"><nlm:aff id="A23">Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Neurology, Juntendo University School of Medicine, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hentati, Faycal" sort="Hentati, Faycal" uniqKey="Hentati F" first="Faycal" last="Hentati">Faycal Hentati</name>
<affiliation wicri:level="1"><nlm:aff id="A24">Service de Neurologie, Institut National de Neurologie, 1007 La Rabta, Tunis, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Service de Neurologie, Institut National de Neurologie, 1007 La Rabta, Tunis</wicri:regionArea>
<wicri:noRegion>Tunis</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ioannidis, John P A" sort="Ioannidis, John P A" uniqKey="Ioannidis J" first="John P. A." last="Ioannidis">John P. A. Ioannidis</name>
<affiliation wicri:level="1"><nlm:aff id="A25">Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina</wicri:regionArea>
<wicri:noRegion>Ioannina</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A26">Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Boczarska Jedynak, Magdalena" sort="Boczarska Jedynak, Magdalena" uniqKey="Boczarska Jedynak M" first="Magdalena" last="Boczarska-Jedynak">Magdalena Boczarska-Jedynak</name>
<affiliation wicri:level="1"><nlm:aff id="A27">Department of Neurology, Medical University of Silesia, Katowice, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Neurology, Medical University of Silesia, Katowice</wicri:regionArea>
<wicri:noRegion>Katowice</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jasinska Myga, Barbara" sort="Jasinska Myga, Barbara" uniqKey="Jasinska Myga B" first="Barbara" last="Jasinska-Myga">Barbara Jasinska-Myga</name>
<affiliation wicri:level="1"><nlm:aff id="A27">Department of Neurology, Medical University of Silesia, Katowice, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Neurology, Medical University of Silesia, Katowice</wicri:regionArea>
<wicri:noRegion>Katowice</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jeon, Beom S" sort="Jeon, Beom S" uniqKey="Jeon B" first="Beom S." last="Jeon">Beom S. Jeon</name>
<affiliation wicri:level="1"><nlm:aff id="A28">Department of Neurology, Seoul National University Hospital, Seoul 110-744, South Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Neurology, Seoul National University Hospital, Seoul 110-744</wicri:regionArea>
<placeName><settlement type="city">Séoul</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kim, Yun Joong" sort="Kim, Yun Joong" uniqKey="Kim Y" first="Yun Joong" last="Kim">Yun Joong Kim</name>
<affiliation wicri:level="1"><nlm:aff id="A29">ILSONG Institute of Life Science and Department of Neurology, Hallym University, Anyang, South Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>ILSONG Institute of Life Science and Department of Neurology, Hallym University, Anyang</wicri:regionArea>
<wicri:noRegion>Anyang</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name>
<affiliation wicri:level="1"><nlm:aff id="A30">Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Luebeck, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Luebeck</wicri:regionArea>
<wicri:noRegion>University of Luebeck</wicri:noRegion>
<wicri:noRegion>University of Luebeck</wicri:noRegion>
<wicri:noRegion>University of Luebeck</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kruger, Rejko" sort="Kruger, Rejko" uniqKey="Kruger R" first="Rejko" last="Kruger">Rejko Kruger</name>
<affiliation wicri:level="1"><nlm:aff id="A31">Department for Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases (DZNE), University of Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department for Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases (DZNE), University of Tübingen</wicri:regionArea>
<wicri:noRegion>University of Tübingen</wicri:noRegion>
<wicri:noRegion>University of Tübingen</wicri:noRegion>
<wicri:noRegion>University of Tübingen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kyratzi, Elli" sort="Kyratzi, Elli" uniqKey="Kyratzi E" first="Elli" last="Kyratzi">Elli Kyratzi</name>
<affiliation wicri:level="1"><nlm:aff id="A32">Divisions of Basic Neurosciences and Cell Biology, Biomedical Research Foundation of the Academy of Athens, Athens 11527, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Divisions of Basic Neurosciences and Cell Biology, Biomedical Research Foundation of the Academy of Athens, Athens 11527</wicri:regionArea>
<wicri:noRegion>Athens 11527</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lesage, Suzanne" sort="Lesage, Suzanne" uniqKey="Lesage S" first="Suzanne" last="Lesage">Suzanne Lesage</name>
<affiliation wicri:level="1"><nlm:aff id="A8">Université Pierre et Marie Curie-Paris6, Centre de Recherche de l’Institut du Cerveau et de la Moelle épinière, UMR-S975, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Pierre et Marie Curie-Paris6, Centre de Recherche de l’Institut du Cerveau et de la Moelle épinière, UMR-S975, Paris</wicri:regionArea>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A9">Inserm, U975, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm, U975, Paris</wicri:regionArea>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A10">Cnrs, UMR 7225, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Cnrs, UMR 7225, Paris</wicri:regionArea>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lin, Chin Hsien" sort="Lin, Chin Hsien" uniqKey="Lin C" first="Chin-Hsien" last="Lin">Chin-Hsien Lin</name>
<affiliation wicri:level="1"><nlm:aff id="A33">Department of Neurology, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Neurology, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin</wicri:regionArea>
<wicri:noRegion>Yun-Lin</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lynch, Timothy" sort="Lynch, Timothy" uniqKey="Lynch T" first="Timothy" last="Lynch">Timothy Lynch</name>
<affiliation wicri:level="1"><nlm:aff id="A34">Dublin Neurological Institute at the Mater Misericordiae University Hospital, and Conway Institute of Biomolecular & Biomedical Research, University College Dublin, Ireland</nlm:aff>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>Dublin Neurological Institute at the Mater Misericordiae University Hospital, and Conway Institute of Biomolecular & Biomedical Research, University College Dublin</wicri:regionArea>
<wicri:noRegion>University College Dublin</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name>
<affiliation wicri:level="2"><nlm:aff id="A35">Department of Neurology, NorthShore University HealthSystem, Evanston, IL</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Department of Neurology, NorthShore University HealthSystem, Evanston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D." last="Mellick">George D. Mellick</name>
<affiliation wicri:level="1"><nlm:aff id="A36">Eskitis Institute for Cell and Molecular Therapies, Griffith University, Queensland, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Eskitis Institute for Cell and Molecular Therapies, Griffith University, Queensland</wicri:regionArea>
<wicri:noRegion>Queensland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mutez, Eugenie" sort="Mutez, Eugenie" uniqKey="Mutez E" first="Eugénie" last="Mutez">Eugénie Mutez</name>
<affiliation wicri:level="1"><nlm:aff id="A14">University Lille Nord de France, Centre de recherche Jean-Pierre Aubert, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Lille Nord de France, Centre de recherche Jean-Pierre Aubert, Lille</wicri:regionArea>
<placeName><settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A15">INSERM, U837, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM, U837, Lille</wicri:regionArea>
<placeName><settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A37">Centre Hospitalier Regional Universitaire de Lille, 59037 Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Hospitalier Regional Universitaire de Lille, 59037 Lille</wicri:regionArea>
<placeName><region type="region" nuts="2">Nord-Pas-de-Calais-Picardie</region>
<region type="old region" nuts="2">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
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<country xml:lang="fr">Corée du Sud</country>
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</affiliation>
</author>
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<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Neurology, Skåne University Hospital, Lund</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:aff id="A42">Department of Neurology, Clinical Sciences, Lund University, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Neurology, Clinical Sciences, Lund University</wicri:regionArea>
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<author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name>
<affiliation wicri:level="1"><nlm:aff id="A43">Department of Medical Sciences, Institute of Neurology, University Magna Graecia, and Neuroimaging Research Unit, National Research Council, Catanzaro, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Medical Sciences, Institute of Neurology, University Magna Graecia, and Neuroimaging Research Unit, National Research Council, Catanzaro</wicri:regionArea>
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</affiliation>
</author>
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<affiliation wicri:level="1"><nlm:aff id="A31">Department for Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases (DZNE), University of Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department for Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases (DZNE), University of Tübingen</wicri:regionArea>
<wicri:noRegion>University of Tübingen</wicri:noRegion>
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<wicri:noRegion>University of Tübingen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A." last="Silburn">Peter A. Silburn</name>
<affiliation wicri:level="1"><nlm:aff id="A44">University of Queensland, Centre for Clinical Research, Royal Brisbane Hospital, Australia</nlm:aff>
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<wicri:regionArea>University of Queensland, Centre for Clinical Research, Royal Brisbane Hospital</wicri:regionArea>
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</author>
<author><name sortKey="Sohn, Young Ho" sort="Sohn, Young Ho" uniqKey="Sohn Y" first="Young Ho" last="Sohn">Young Ho Sohn</name>
<affiliation wicri:level="3"><nlm:aff id="A45">Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
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</affiliation>
</author>
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<affiliation wicri:level="1"><nlm:aff id="A46">Neurodegenerative Brain Diseases group, Department of Molecular Genetics, VIB, Antwerp, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Neurodegenerative Brain Diseases group, Department of Molecular Genetics, VIB, Antwerp</wicri:regionArea>
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<affiliation wicri:level="4"><nlm:aff id="A47">Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium</nlm:aff>
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<wicri:regionArea>Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp</wicri:regionArea>
<orgName type="university">Université d'Anvers</orgName>
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<author><name sortKey="Tomiyama, Hiroyuki" sort="Tomiyama, Hiroyuki" uniqKey="Tomiyama H" first="Hiroyuki" last="Tomiyama">Hiroyuki Tomiyama</name>
<affiliation wicri:level="3"><nlm:aff id="A23">Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Neurology, Juntendo University School of Medicine, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Uitti, Ryan J" sort="Uitti, Ryan J" uniqKey="Uitti R" first="Ryan J." last="Uitti">Ryan J. Uitti</name>
<affiliation wicri:level="2"><nlm:aff id="A48">Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Mayo Clinic, Jacksonville, Florida</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Valente, Enza Maria" sort="Valente, Enza Maria" uniqKey="Valente E" first="Enza Maria" last="Valente">Enza Maria Valente</name>
<affiliation wicri:level="1"><nlm:aff id="A40">IRCCS Casa Sollievo della Sofferenza Hospital, Mendel Laboratory, San Giovanni Rotondo, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>IRCCS Casa Sollievo della Sofferenza Hospital, Mendel Laboratory, San Giovanni Rotondo</wicri:regionArea>
<wicri:noRegion>San Giovanni Rotondo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Broeckhoven, Christine" sort="Van Broeckhoven, Christine" uniqKey="Van Broeckhoven C" first="Christine" last="Van Broeckhoven">Christine Van Broeckhoven</name>
<affiliation wicri:level="1"><nlm:aff id="A46">Neurodegenerative Brain Diseases group, Department of Molecular Genetics, VIB, Antwerp, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Neurodegenerative Brain Diseases group, Department of Molecular Genetics, VIB, Antwerp</wicri:regionArea>
<wicri:noRegion>Antwerp</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A47">Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp</wicri:regionArea>
<orgName type="university">Université d'Anvers</orgName>
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<author><name sortKey="Van De Loo, Simone" sort="Van De Loo, Simone" uniqKey="Van De Loo S" first="Simone" last="Van De Loo">Simone Van De Loo</name>
<affiliation wicri:level="1"><nlm:aff id="A4">Department of Neurology, Goethe University Frankfurt am Main, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
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<affiliation wicri:level="1"><nlm:aff id="A32">Divisions of Basic Neurosciences and Cell Biology, Biomedical Research Foundation of the Academy of Athens, Athens 11527, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Divisions of Basic Neurosciences and Cell Biology, Biomedical Research Foundation of the Academy of Athens, Athens 11527</wicri:regionArea>
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</affiliation>
</author>
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<affiliation wicri:level="1"><nlm:aff id="A49">Department of Medical Genetics, University of British Columbia, Vancouver, V5Z 4H4 BC, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Medical Genetics, University of British Columbia, Vancouver, V5Z 4H4 BC</wicri:regionArea>
<wicri:noRegion>V5Z 4H4 BC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="White, Linda R" sort="White, Linda R" uniqKey="White L" first="Linda R." last="White">Linda R. White</name>
<affiliation wicri:level="3"><nlm:aff id="A50">University Hospital and NTNU, Trondheim, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>University Hospital and NTNU, Trondheim</wicri:regionArea>
<placeName><settlement type="city">Trondheim</settlement>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Wirdefeldt, Karin" sort="Wirdefeldt, Karin" uniqKey="Wirdefeldt K" first="Karin" last="Wirdefeldt">Karin Wirdefeldt</name>
<affiliation wicri:level="3"><nlm:aff id="A51">Department of Clinical Neuroscience and Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Clinical Neuroscience and Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name>
<affiliation wicri:level="4"><nlm:aff id="A47">Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp</wicri:regionArea>
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<author><name sortKey="Wu, Ruey Meei" sort="Wu, Ruey Meei" uniqKey="Wu R" first="Ruey-Meei" last="Wu">Ruey-Meei Wu</name>
<affiliation wicri:level="1"><nlm:aff id="A52">Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J." last="Farrer">Matthew J. Farrer</name>
<affiliation wicri:level="1"><nlm:aff id="A49">Department of Medical Genetics, University of British Columbia, Vancouver, V5Z 4H4 BC, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Medical Genetics, University of British Columbia, Vancouver, V5Z 4H4 BC</wicri:regionArea>
<wicri:noRegion>V5Z 4H4 BC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ross, Owen A" sort="Ross, Owen A" uniqKey="Ross O" first="Owen A." last="Ross">Owen A. Ross</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida</wicri:regionArea>
<placeName><region type="state">Floride</region>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2013">2013</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Gene Frequency</term>
<term>Genetic Association Studies</term>
<term>Genetic Predisposition to Disease</term>
<term>Genetics, Population</term>
<term>Genotype</term>
<term>Haplotypes</term>
<term>Humans</term>
<term>Molecular Epidemiology</term>
<term>Parkinson Disease (epidemiology)</term>
<term>Parkinson Disease (genetics)</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Protein-Serine-Threonine Kinases (genetics)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Protein-Serine-Threonine Kinases</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Gene Frequency</term>
<term>Genetic Association Studies</term>
<term>Genetic Predisposition to Disease</term>
<term>Genetics, Population</term>
<term>Genotype</term>
<term>Haplotypes</term>
<term>Humans</term>
<term>Molecular Epidemiology</term>
<term>Polymorphism, Single Nucleotide</term>
</keywords>
</textClass>
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<front><div type="abstract" xml:lang="en"><p id="P1">Variants within the leucine-rich repeat kinase 2 gene are recognized as the most frequent genetic cause of Parkinson’s disease. Leucine-rich repeat kinase 2 variation related to susceptibility to disease displays many features that reflect the nature of complex late-onset sporadic disorders, such as Parkinson’s disease. The Genetic Epidemiology of Parkinson’s disease consortium recently performed the largest genetic association study for variants in the leucine-rich repeat kinase 2 gene across 23 different sites in 15 countries. Herein we detail the allele frequencies for the novel risk factors (p.A419V and p.M1646T) and the protective haplotype (p.N551K-R1398H-K1423K) reported in the original publication. Simple population allele frequencies can not only provide an insight into the clinical relevance of specific variants but also help genetically define patient groups. Establishing individual patient-based genomic susceptibility profiles incorporating both risk and protective factors will determine future diagnostic and treatment strategies.</p>
</div>
</front>
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Movement Disorders (revue)

Population-specific frequencies for LRRK2 susceptibility variants in the Genetic Epidemiology Of Parkinson’s Disease (GEO-PD) consortium

Population-specific frequencies for LRRK2 susceptibility variants in the Genetic Epidemiology Of Parkinson’s Disease (GEO-PD) consortium

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	Movement Disorders (revue)
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